Prednisone Drug Interactions

If you take medications such as estrogens or barbiturates with prednisone, drug interactions may potentially occur. These interactions can increase your risk of side effects, affect the level of prednisone in your blood, or decrease the effectiveness of some medications. Besides those mentioned above, some other drugs that may potentially cause prednisone interactions include nonsteroidal anti-inflammatory drugs, salicylates, rifamycin antibiotics, and certain diuretics.

 

An Overview of Prednisone Drug Interactions

Prednisone can potentially interact with certain other medications. Some of these medicines that may lead to prednisone drug interactions include:
 
  • Barbiturates, including:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Certain diuretics, such as:

 

 

 

 

  • Mifepristone (Mifeprex®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

 

 

  • Phenytoin (Dilantin®, Phenytek®) or fosphenytoin (Cerebyx®)
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Salicylates, such as aspirin (Ecotrin®, Bayer®, Anacin®), choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®), and salsalate (Salflex®, Disalcid®, Amigesic®)
  • Warfarin (Coumadin®, Jantoven®).
     
(Prednisone Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;