If you take medications such as estrogens or barbiturates with prednisone, drug interactions may potentially occur. These interactions can increase your risk of side effects, affect the level of prednisone in your blood, or decrease the effectiveness of some medications. Besides those mentioned above, some other drugs that may potentially cause prednisone interactions include nonsteroidal anti-inflammatory drugs, salicylates, rifamycin antibiotics, and certain diuretics.