Medications that may cause drug interactions with pravastatin include fibrates, erythromycin, niacin, and many others. These drug interactions may result in side effects or complications such as increased levels of medicine in the blood and an increased risk of developing serious muscle problems.
Some of these drug interactions may increase your risk for developing serious muscle problems (see Pravachol and Muscle Pain). If you experience unexplained muscle pain, tenderness, or weakness while taking pravachol (especially if you also have a fever or feel ill), it is important to contact your healthcare provider immediately.