Drug Interactions With Pravastatin (Cont.)

 
Niacin (Nicotinic Acid, Niacor, Nicolar)
Taking either niacin or pravastatin alone can increase the chances for developing serious muscle problems. Therefore, it is thought that when these medicines are combined, they may cause an even greater risk. If you are taking pravastatin with niacin, your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments (see Niacin and Pravachol).
 
Antifungals [Ketoconazole (Nizoral), Fluconazole (Diflucan), Itraconazole (Sporanox)]
There is a possibility that, when pravastatin is taken with these medications, you are at higher risk of developing muscle problems. Unless your healthcare provider feels that the benefits outweigh the risks, these medicines should not be taken together.
 
Erythromycin, Clarithromycin, and Telithromycin
If you are taking pravastatin with erythromycin, clarithromycin, or telithromycin, your body may metabolize the medicines differently than intended. This can cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Unless your healthcare provider feels that the benefits outweigh the risks, these medicines should not be taken together.
 
HIV Protease Inhibitors
If you are taking pravastatin with an HIV protease inhibitor, your body may metabolize the medicines differently than intended. This can cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Unless your healthcare provider feels that the benefits outweigh the risks, these medicines should not be taken together.
 
Examples of HIV protease inhibitors include:
 
Nefazodone (Serzone)
If you are taking both pravastatin and nefazodone, your body may metabolize the medicines differently than intended. This can cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Unless your healthcare provider feels that the benefits outweigh the risks, these medicines should not be taken together.
(Drug Interactions With Pravastatin Continued: Page 4)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;