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Drug Interactions With Pravastatin

More Detail About Pravastatin Interactions

The following sections explain in detail the potentially negative interactions that can occur when pravastatin is combined with any of the drugs listed above.
 
Certain Antifungals
Some antifungal medications may slightly increase the level of pravastatin in your blood. There is a possibility that, when pravastatin is taken with these medications, you may be at higher risk of developing muscle problems. Unless your healthcare provider feels that the benefits outweigh the risks, these medicines should not be taken together.
 
Cyclosporine
There is conflicting information about whether cyclosporine can increase the level of pravastatin in your blood (which could cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis). Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments if you take these medications together. A lower starting pravastatin dosage (10 mg daily) is recommended for people taking cyclosporine.
 
Erythromycin
Combining erythromycin with other statin medications (similar to pravastatin) has been reported to increase the risk of serious muscle problems like myopathy or rhabdomyolysis. It is not clear if this is also a problem with pravastatin. Check with your healthcare provider before taking these medications together.
 
Fibrates
If you are taking both pravastatin and a fibrate, you may have an increased risk for serious reactions, including serious muscle problems like myopathy or rhabdomyolysis, since both medications can cause such problems individually. The combination of gemfibrozil and pravastatin should be avoided if possible. With the other fibrates, careful monitoring may be required when used in combination with pravastatin.
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