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Drug Interactions With Pomalidomide

More Detail on Drug Interactions With Pomalidomide

The following sections explain in detail the potentially negative interactions that can occur when pomalidomide is combined with any of the drugs listed above.
 
Biologic and Immunologic Medications
Taking pomalidomide with certain medications that suppress the immune system may increase your risk for side effects, including low blood cell counts and potentially serious infections. Talk to your healthcare provider before taking these medicines together.
 
Cigarette Smoking
Smoking cigarettes causes your body to break down pomalidomide faster than normal, which could make pomalidomide less effective. If you currently smoke, talk to your healthcare provider about ways to quit. 
 
Clozapine
Taking clozapine with pomalidomide may increase the risk of dangerously low white blood cells, which would increase your risk for infections. Talk to your healthcare provider before taking these medicines together. However, do not stop taking clozapine without first speaking with your healthcare provider.
 
Strong CYP 1A2 Inhibitor Medications
The liver breaks down pomalidomide using enzymes known as CYP 1A2 enzymes, and medications known as CYP 1A2 inhibitors can decrease the activity of these enzymes. Thus, combining pomalidomide with one of these drugs may increase the level of pomalidomide in your body, increasing your risk for side effects. The manufacturer of pomalidomide recommends it not be used with a strong CYP 1A2 inhibitor. 
 
Strong CYP 3A4 Inducer Medications
The liver breaks down pomalidomide using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining pomalidomide with one of these drugs may decrease the level of pomalidomide in your body, potentially making it less effective. The manufacturer of pomalidomide recommends it not be used with a strong CYP 3A4 inducer. 
 
Strong CYP 3A4 Inhibitor Medications
The liver breaks down pomalidomide using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining pomalidomide with one of these drugs may increase the level of pomalidomide in your body, increasing your risk for side effects. The manufacturer of pomalidomide recommends it not be used with a strong CYP 3A4 inhibitor. 
 
Echinacea
Echinacea may decrease the effectiveness of pomalidomide. Check with your healthcare provider before taking echinacea during pomalidomide treatment.
 
Live Vaccinations
Live vaccines are vaccines that contain live viruses or bacteria. If you receive a live vaccine while taking pomalidomide, you could become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people taking pomalidomide. Talk to your healthcare provider before receiving a vaccination during pomalidomide treatment.
 
Medications That Cause Drowsiness
Pomalidomide can cause dizziness and confusion. Medicines that make you drowsy can also cause you to feel dizzy and confused, which could add to the effects of pomalidomide. In general, pomalidomide should be used cautiously with any medicine that causes drowsiness, dizziness, or confusion. Talk to your healthcare provider before taking these medicines together.  
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, out of the tissues in the body so they can be removed through the urine or feces. Pgp helps remove pomalidomide from the body. Certain other medications known as Pgp inducers increase the activity of Pgp.
 
Taking pomalidomide with one of these drugs may cause pomalidomide to be removed from the body too quickly, potentially making it less effective. The manufacturer of pomalidomide recommends these medicines not be used together.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, out of the tissues so they can be excreted through the urine or feces. Pgp helps remove pomalidomide from the body. Certain other medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking pomalidomide with one of these drugs may cause pomalidomide to be removed more slowly than normal, potentially increasing the amount of pomalidomide in your body and increasing your risk for serious side effects. The manufacturer of pomalidomide recommends these medicines not be used together.
 
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Pomalidomide Drug Information

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