Drug Interactions With Polyethylene Glycol Electrolyte Solution

Several medications, such as certain diuretics, antacids, and nonsteroidal anti-inflammatory drugs, can interact with polyethylene glycol electrolyte solution. Some of these reactions may increase the risk for electrolyte problems. Also, if you take medications within one hour of starting polyethylene glycol electrolyte solution, the medications could be flushed out of the gastrointestinal tract before your body has a chance to absorb them.

An Overview of Polyethylene Glycol Electrolyte Solution Interactions

 Polyethylene glycol electrolyte solution (colyte®, GoLYTELY®, MoviPrep®, NuLYTELY®, TriLyte®) is a prescription medication licensed to cleanse the bowel before a colonoscopy or barium enema x-ray examination. This laxative may potentially interact with many other medications.
 
Some of the medications that may lead to polyethylene glycol electrolyte solution drug interactions include but are not limited to:
 
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

  
  • Antacids (Alternagel®, Gaviscon®, Maalox®, Mylanta®, Tums®, and many others)
  • Diuretics, such as:
 
 
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
  • Oral medications taken within one hour of the first dose of polyethylene glycol electrolyte solution.
 
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Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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