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Phenergan Effects

Phenergan® (promethazine hydrochloride) is a prescription medication used for a wide variety of different purposes. It has several different effects in the body and the brain. Many of the effects of Phenergan are most likely due to the drug's antihistamine activity since it works by blocking histamine receptors.
There are several approved uses for Phenergan. The medicine is effective for:
  • Treating or preventing nausea and vomiting related to surgery and general anesthesia (see Phenergan for Nausea)
  • Treating or preventing motion sickness
  • Treating the following conditions:
    • Perennial (year-round) or seasonal allergies
    • Nonallergic nasal symptoms due to irritants
    • "Allergy eyes" (allergic conjunctivitis)
    • Hives
    • Allergic reactions to blood or plasma transfusions
    • Severe, anaphylactic allergic reactions (when used with other medications)
  • Causing sedation in the following situations:
    • Before or after surgery
    • During labor
    • In situations when mild anxiety relief and light sleep is desired.
(Click Phenergan Uses to learn more about specific Phenergan effects, for information about using it in children, and to find out how this medication can be used for "off-label" purposes.)
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