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Phenergan Drug Interactions
If pramlintide, anticholinergic drugs, or monoamine oxidase inhibitors are taken together with Phenergan, drug interactions may occur. These interactions may lead to undesirable side effects (such as drowsiness or dizziness) or reduce the effectiveness of the medications. Many other medicines may also cause drug interactions with Phenergan, so make sure to tell your healthcare provider about all other medications you are taking before starting treatment.
Phenergan® (promethazine hydrochloride) can potentially interact with several other medications. Some of the medicines that may lead to drug interactions with Phenergan include:
- Alcohol
- Acetylcholinesterase inhibitor medications, such as:
- Donepezil (Aricept®)
- Galantamine (Razadyne™)
- Rivastigmine (Exelon®)
- Tacrine (Cognex®)
- Anticholinergic drugs, such as:
- Atropine
- Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
- Benztropine (Cogentin®)
- Clidinium (Librax®)
- Clozapine (Clozaril®)
- Darifenacin (Enablex®)
- Diphenhydramine (Benadryl®)
- Dicyclomine (Bentyl®)
- Glycopyrrolate (Robinul®)
- Haloperidol (Haldol®)
- Homatropine (Hycodan®)
- Hyoscyamine (Levsin®)
- Ipratropium (Atrovent®)
- Oxybutynin (Ditropan®, Ditropan XL®, Oxytrol®)
- Solifenacin (VESIcare®)
- Scopolamine (Transderm Scop®)
- Tiotropium (Spiriva®)
- Tolterodine (Detrol®, Detrol® LA)
- CYP 2B6 inhibitor medications, such as:
- Desipramine (Norpramin®)
- Doxorubicin (Adriamycin®, Doxil®)
- Miconazole
- Paroxetine (Paxil®, Paxil CR®, Pexeva®)
- Sertraline (Zoloft®)
- Sorafenib (Nexavar®)
- Thiotepa
- CYP 2D6 inhibitor medications, such as:
- Chlorpromazine
- Cinacalcet (Sensipar®)
- Cocaine
- Delavirdine (Rescriptor®)
- Fluoxetine (Prozac®, Sarafem®, Selfemra™)
- Lopinavir and ritonavir (Kaletra®)
- Miconazole
- Paroxetine (Paxil®, Paxil CR®, Pexeva®)
- Quinidine
- Quinine
- Ritonavir (Norvir®)
- Terbinafine (Lamisil®)
- Epinephrine
- Monoamine oxidase inhibitors (MAOIs), such as:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Other medications that cause drowsiness, such as:
- Antipsychotic medications
- Anxiety medications
- Most antidepressants
- Muscle relaxants
- Narcotic pain relievers
- Sleep medications
- Some antihistamines
- Pramlintide (Symlin®).
It should be noted that this article applies only to Phenergan products that contain only promethazine as the active ingredient. Some cough syrups (such as Phenergan with Codeine) contain other active ingredients as well.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD