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Drug Interactions With Pentazocine/Naloxone

More Detail on Drug Interactions With Pentazocine/Naloxone

The following sections explain in detail the potentially negative reactions that can occur when pentazocine/naloxone is combined with any of the drugs listed above.
Consuming alcohol while using pentazocine/naloxone could potentially increase your risk for serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Do not drink alcohol while taking this medication.
The manufacturer of alvimopan recommends it not be used in people who have been taking opioid medications, such as pentazocine/naloxone, for seven or more consecutive days immediately before alvimopan is to be started. This is because opioids can increase the risk for alvimopan side effects. Alvimopan is a medication used in people who have just had bowel surgery.
Azelastine Nasal Spray
Combining azelastine with narcotic pain medications, such as pentazocine/naloxone, may increase your risk for drowsiness and decrease your alertness. Talk with your healthcare provider before using these medications together.
Medications That Cause Drowsiness
Pentazocine/naloxone can cause significant drowsiness. Taking other medications that cause drowsiness while using pentazocine/naloxone may lead to serious side effects, such as extreme sedation, confusion, and serious breathing problems. Check with your healthcare provider before taking pentazocine/naloxone with other medications that can cause drowsiness. 
Monoamine Oxidase Inhibitors (MAOIs)
Combining pentazocine/naloxone with an MAOI may lead to dangerously high blood pressure. Do not use pentazocine/naloxone if you have taken an MAOI within the past 14 days.
Other Opioids
Pentazocine/naloxone can make other opioids less effective. In addition, because pentazocine/naloxone contains naloxone, it could cause withdrawal symptoms if taken in combination with other opioid medications. Naloxone binds to and blocks opioid receptors in the body. If you abuse pentazocine/naloxone by injection and are taking other opioids, you may experience intense withdrawal symptoms.
Certain Tobacco Products
Tobacco smoking can cause the body to remove pentazocine/naloxone faster than usual, potentially making it less effective at reducing pain. Make sure your healthcare provider knows if you smoke tobacco products, such as cigarettes.
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Pentazocine/Naloxone Information

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