Drug Interactions With Peginterferon Alfa-2b

If you are receiving injections of peginterferon alfa-2b, you may not be able to take aldesleukin, methadone, or theophylline products, among other medications. Interactions may occur when drugs such as these are combined with peginterferon alfa-2b. These reactions may lead to bothersome side effects, decrease the effectiveness of the medicines, or cause other complications.

Peginterferon Alfa-2b Drug Information

An Overview of Peginterferon Alfa-2b Interactions

Peginterferon alfa-2b (PegIntron^®, Sylatron^®) may react with several other medications. Some of the drugs that may interact with peginterferon alfa-2b include but are not limited to:

Aldesleukin (Proleukin^®)
Fluoxetine (Prozac^®, Sarafem^®, Symbyax^®)
Methadone (Dolophine^®, Methadose^®)
Pegloticase (Krystexxa™)
Telbivudine (Tyzeka^®)
Theophylline products (Elixophyllin^®, Theo-24^®, TheoCap™, Theochron^®, Uniphyl^®)
Zidovudine (Retrovir^®) or combination medications that contain zidovudine (Combivir^®, Trizivir^®).

More Detail on Drug Interactions With Peginterferon Alfa-2b

The following sections explain in detail the potentially negative interactions that can occur when peginterferon alfa-2b is combined with any of the drugs listed above.

Aldesleukin

Interferons like peginterferon alfa-2b may increase the risk of aldesleukin side effects. In general, these drugs should not be combined.

Fluoxetine

Peginterferon alfa-2b may decrease the level of fluoxetine in the blood, making it less effective. Check with your healthcare provider before using these medications together.

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