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Pantoprazole Drug Interactions
In the case of pantoprazole, drug interactions can occur with medications such as ketoconazole and ampicillin esters. Other potential drug interactions with pantoprazole may involve warfarin. Iron salts also have the potential to interact with pantoprazole.
Pantoprazole sodium ("pantoprazole") -- sold under the brand name Protonix® -- potentially has a number of medicines with which it can interact. Examples of such medications include:
- Atazanavir (Reyataz®)
- Clopidogrel (Plavix®)
- Digoxin (Digitek®, Lanoxin®)
- Certain diuretics, such as:
- Bumetanide (Bumex®)
- Chlorothiazide (Diuril®)
- Chlorthalidone (Thalitone®)
- Ethacrynic acid (Edecrin®)
- Furosemide (Lasix®)
- Hydrochlorothiazide (Esidrix®, HydroDIURIL®, Microzide®, Oretic®)
- Metolazone (Zaroxolyn®)
- Torsemide (Demadex®)
- Iron salts
- Ampicillin esters (bacampicillin, pivampicillin)
- Ketoconazole (Nizoral®)
- Methotrexate (Rheumatrex®, Trexall®)
- Warfarin (Coumadin®, Jantoven®).
Atazanavir
Taking atazanavir with medications like pantoprazole can significantly decrease the level of atazanavir in your blood, perhaps making it less effective. It is not recommended to take these medications together.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD