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Drug Interactions With Oxytocin

When oxytocin is combined with misoprostol or dinoprostone products, it may lead to complications. Drug interactions such as these may increase the effects of oxytocin, resulting in abnormally strong or frequent contractions. To avoid problems, your healthcare provider may not recommend some of these products together or may not administer oxytocin until several hours after a woman has received dinoprostone or misoprostol.

An Overview of Oxytocin Interactions

Oxytocin (Pitocin®) can potentially react with a couple of other medications. Some of the products that may lead to drug interactions with oxytocin include:
 
 

More Detail on Drug Interactions With Oxytocin

The following sections explain in detail the potentially negative interactions that can occur when oxytocin is combined with any of the drugs listed above.
 
Dinoprostone
Dinoprostone may increase the effects of oxytocin, potentially causing abnormally strong or frequent contractions. To minimize the risk for this interaction, oxytocin should be given at least 30 minutes after dinoprostone vaginal insert is removed and at least 6 to 12 hours after dinoprostone vaginal gel is given. It is generally recommended that dinoprostone vaginal suppository not be used in combination with oxytocin.
 
Misoprostol
Misoprostol may increase the effects of oxytocin, potentially causing abnormally strong or frequent contractions. Giving oxytocin 6 to 12 hours after misoprostol may help reduce the risk for this interaction.
 
Pregnancy and Pain

Oxytocin Medication Information

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