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Side Effects of Oxycodone ER

Common Side Effects

Oxycodone ER has been studied extensively in clinical trials. In these studies, side effects occurring in the group of people taking oxycodone ER are documented and compared to the side effects that occur in a similar group of people taking either a placebo (a "sugar pill" with no active ingredients) or the short-acting version of oxycodone.
Based on these studies, the most common bothersome (but not usually dangerous) side effects included:
  • Constipation -- in up to 23 percent of people (see OxyContin and Constipation)
  • Nausea -- up to 23 percent
  • Drowsiness -- up to 23 percent
  • Dizziness -- up to 13 percent
  • Itching -- up to 13 percent
  • Vomiting -- up to 12 percent
  • Dry mouth -- up to 6 percent
  • Weakness -- up to 6 percent
  • Sweating -- up to 5 percent.


Other common side effects of oxycodone ER (occurring in 1 to 5 percent of people) included but were not limited to:
  • Loss of appetite
  • Insomnia or abnormal dreams
  • Fever or chills
  • Abdominal pain (stomach pain), diarrhea, indigestion, or heartburn
  • Nervousness, anxiety, or an unusual pleasant feeling (euphoria)
  • Shortness of breath
  • Twitching
  • Hiccups. 


It is common to develop non-allergic itching due to oxycodone ER. The medication causes a release of histamine, resulting in itching unrelated to any allergy. If you develop itching but no other allergy symptoms, it is unlikely that you are allergic to oxycodone ER. Tell your healthcare provider, though, since there are medications available to help relieve the itching.
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Oxycodone ER Drug Information

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