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Precautions and Warnings With Oral Tranexamic Acid

Oral tranexamic acid may not be the best choice for women with irregular periods. In addition, this medication puts you at a higher risk for blood clots, including blood clots in the eyes. To help reduce your risk of problems, talk to your healthcare provider about the specific oral tranexamic acid warnings and precautions that apply to you before starting treatment.

What Should I Tell My Healthcare Provider Before Beginning Treatment?

Prior to taking oral tranexamic acid (Lysteda™), talk to your healthcare provider if you:
  • Have ever had a blood clot
  • Are at a high risk for blood clots
  • Use hormonal contraceptives
  • Have irregular menstrual periods
  • Have a short menstrual cycle (21 days or shorter)
  • Have a long menstrual cycle (35 days or longer)
  • Have kidney disease, such as kidney failure (renal failure)
  • Have a subarachnoid hemorrhage
  • Have heart valve disease or an irregular heart rhythm
  • Have any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Oral Tranexamic Acid Precautions and Warnings

Warnings and precautions to be aware of prior to taking this medicine include the following:
  • Oral tranexamic acid may increase the risk of blood clots. A history of blood clots, genetic clotting disorders, and hormonal contraceptive use may increase this risk. Hormonal contraceptives include any type of birth control that contains hormones, such as birth control pills, patches, rings, and some intrauterine devices (IUDs).
  • In rare cases, this drug may cause severe allergic reactions. Seek immediate medical attention if you develop signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
  • Oral tranexamic acid can cause blood clots in the eyes. If you develop any vision changes or eye problems while taking this medicine, contact your healthcare provider right away.
  • You should not take this medication if you have a subarachnoid hemorrhage (bleeding between the brain and the thin covering of the brain), as fluid accumulation in the brain and a stroke may occur.
  • Oral tranexamic acid can potentially interact with a few other medications (see Drug Interactions With Oral Tranexamic Acid).
  • Oral tranexamic acid is approved for use only in women with periods that occur at normal intervals. If your periods are more frequent, less frequent, or are otherwise irregular, a different treatment approach may be better.
  • Oral tranexamic acid is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known (see Lysteda and Pregnancy). It is important to note that oral tranexamic acid is not intended for use during pregnancy.
  • This medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to beginning treatment (see Lysteda and Breastfeeding).
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Oral Tranexamic Acid Information

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