Drug Interactions With Oral Tranexamic Acid

Problems can occur when certain drugs (such as Activase, hormonal contraceptives, or Vesanoid) are taken with oral tranexamic acid. Drug interactions with this product can lead to an increased risk of blood clots and reduced effectiveness of the medications. To help ensure a safe, effective treatment process, talk to your healthcare provider about the interactions that apply to you.

An Overview of Oral Tranexamic Acid Interactions

Oral tranexamic acid (Lysteda™) can potentially interact with a few other medications. Some of the medicines that may lead to drug interactions with oral tranexamic acid include (but are not limited to):
 
  • Alteplase (Activase®)
  • Anti-inhibitor coagulant concentrates (Autoplex-T, Feiba VH)
  • Factor IX complex concentrates
  • Hormonal contraceptives
  • Oral tretinoin (Vesanoid®).
     

More Information on Drug Interactions With Oral Tranexamic Acid

The following sections explain in detail the potentially negative interactions that can occur when oral tranexamic acid is combined with any of the drugs listed above.
 
 
Alteplase
Oral tranexamic acid and alteplase work in opposite ways. Taking them together may decrease the effectiveness of both medications.
 
Anti-inhibitor Coagulant Concentrates
It is not recommended that women take both an anti-inhibitor coagulant concentrate and oral tranexamic acid, as this combination increases the risk of blood clots.
 
Factor IX Complex Concentrates
It is not recommended for women to take both a factor IX complex concentrate and oral tranexamic acid, as this combination increases the risk of blood clots.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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