Ondansetron is considered a pregnancy Category B medication. This means that ondansetron is probably safe for use during pregnancy. However, because ondansetron has not been studied in pregnant women, the full risks of using ondansetron during pregnancy are not known. Women who are pregnant should take ondansetron only if the benefits of taking ondansetron outweigh the risks to the developing baby. Be sure to discuss ondansetron's possible risks and benefits with your healthcare provider before using ondansetron during pregnancy (see Zofran During Pregnancy for more information).
It is not known if ondansetron can pass through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about this. He or she can decide whether taking ondansetron while nursing would be okay for your particular situation.
Ondansetron does not increase the activity or movement of the gastrointestinal tract and should not be used for this purpose. Using ondansetron after abdominal surgery or chemotherapy may mask the symptoms of an intestinal blockage (abdominal ileus). Talk to your healthcare provider right away if you are severely constipated or have abdominal cramping or bloating, as this may be a sign of intestinal blockage.
In very rare cases, ondansetron (especially the injectable version) can cause changes in heart rhythm, including a specific type of arrhythmia called QT prolongation. People with long QT syndrome should not take ondansetron.
Ondansetron orally disintegrating tablets (ODTs) contain phenylalanine (less than 0.03 mg per tablet). This is important for people with phenylketonuria, as they must limit their intake of phenylalanine.
The dose of ondansetron must be reduced in people will poor liver function. The maximum dose of ondansetron for people with severe liver problems is 8 mg per day.
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