Drug Interactions With Ondansetron

There are several potential drug interactions with ondansetron. Taking ondansetron along with other medications, such as carbamazepine or phenytoin, can decrease the level of ondansetron in your blood. However, for most people, this interaction does not cause any problems. Prior to taking ondansetron, talk to your healthcare provider about any drug interactions with ondansetron that may apply to your situation.

An Overview of Ondansetron Drug Interactions

Ondansetron hydrochloride (Zofran®) can potentially interact with many drugs. Some of the drugs that may lead to ondansetron interactions include:
 

Ondansetron Interactions Explained

Carbamazepine (Tegretol)
Taking ondansetron with carbamazepine can decrease the level of ondansetron in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
 
Phenytoin (Dilantin)
Taking ondansetron with phenytoin can decrease the level of ondansetron in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
 
Rifampicin (Rifadin)
Taking ondansetron with rifampicin can decrease the level of ondansetron in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
 
Tramadol (Ultram, Ultracet)
Taking ondansetron with tramadol may increase your need for tramadol. Your healthcare provider may need to increase your dose of tramadol.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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