Drug Interactions With Ondansetron

There are several potential drug interactions with ondansetron. Taking ondansetron along with other medications, such as carbamazepine or phenytoin, can decrease the level of ondansetron in your blood. However, for most people, this interaction does not cause any problems. Prior to taking ondansetron, talk to your healthcare provider about any drug interactions with ondansetron that may apply to your situation.

An Overview of Ondansetron Drug Interactions

Ondansetron hydrochloride (Zofran®) can potentially interact with many drugs. Some of the drugs that may lead to ondansetron interactions include:
 

Ondansetron Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when ondansetron is combined with any of the drugs listed above.
 
 
Apomorphine
Due to the risk of dangerously low blood pressure (hypotension) and loss of consciousness, ondansetron and apomorphine should not be combined.
 
Carbamazepine
Taking ondansetron with carbamazepine can decrease the level of ondansetron in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
 
QT-Prolonging Medications
There have been reports of a certain change in heart rhythm (known as QT prolongation) in people taking ondansetron. This heart rhythm change can be dangerous. Check with your healthcare provider before combining ondansetron with other QT-prolonging medications.
  
Phenytoin
Taking ondansetron with phenytoin can decrease the level of ondansetron in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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