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Omeprazole Dosing

General Omeprazole Dosing Information

Some considerations for people taking omeprazole include the following:
  • Omeprazole comes in capsule form or as packets used to mix an oral suspension (liquid). It is taken by mouth once or twice a day. Nonprescription omeprazole comes in tablet and capsule form.
  • Omeprazole is best taken on an empty stomach, half an hour before a meal.
  • Omeprazole capsules should not be chewed or crushed, as they contain tiny granules with a special coating that prevents stomach acid from destroying the medication. Nonprescription omeprazole tablets should not be cut, crushed, or chewed.
  • For people who have difficulty swallowing capsules, Omeprazole capsules (but not tablets) can be opened and the contents sprinkled onto a spoonful of applesauce. The applesauce should not be hot and should be swallowed (without chewing) immediately.


  • For the oral suspension, the contents of one packet are mixed with a certain amount of water (which varies, depending on the strength), left to sit for two or three minutes to thicken, and taken within 30 minutes. Rinse out the container with a small amount of water and drink the contents if any of the drug remains. 


  • Omeprazole should be taken at the same time(s) each day to maintain an even level of the medication in your blood.
  • For the medication to work properly, it must be taken as prescribed. Omeprazole will not work if you stop taking it.
  • If you are unsure about anything related to omeprazole or your omeprazole dosage, talk to your doctor, nurse, or pharmacist. Do not stop taking the drug without discussing it with your healthcare provider.
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