Omeprazole Dosing

The recommended omeprazole dose for stomach ulcers (gastric ulcers) is omeprazole 40 mg once daily for four to eight weeks.

 

The recommended omeprazole dose for gastroesophageal reflux disease (GERD) is omeprazole 20 mg once daily for up to four weeks. For people with GERD and erosive esophagitis, the recommended dose is omeprazole 20 mg for four to eight weeks. Omeprazole can be continued if needed to prevent erosive esophagitis from returning.

 

People with pathological hypersecretory conditions (such as Zollinger-Ellison syndrome) usually require higher omeprazole dosages. The recommended dose is omeprazole 60 mg once daily, although some people may need even higher doses. Doses of omeprazole larger than 80 mg should be split up into two or three smaller doses per day.

 

• Between 5 and 10 kg (11 to 22 pounds) -- omeprazole 5 mg once daily
• Between 10 and 20 kg (22 to 44 pounds) -- omeprazole 10 mg once daily
• 20 kg or more (44 pounds or more) -- omeprazole 20 mg once daily.
   

Nonprescription Omeprazole Dosing

The recommended dose of nonprescription omeprazole magnesium (Prilosec OTC^®) for frequent heartburn is 20 mg once daily for up to fourteen days every four months. It is not recommended to take nonprescription omeprazole long-term without talking with your healthcare provider first, in order to rule out more serious conditions.