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Drug Interactions With Omeprazole

Iron Supplements
Omeprazole can decrease the absorption of iron supplements into your bloodstream, perhaps making them less effective. Your healthcare provider may need to increase your iron dose.
 
Ketoconazole (Nizoral)
Omeprazole can decrease the absorption of ketoconazole into your bloodstream, perhaps making it less effective. Your healthcare provider may need to increase your ketoconazole dose.
 
Methotrexate
Omeprazole might increase the level of methotrexate in the blood, increasing the risk for methotrexate side effects. Check with your healthcare provider before combining these two medications.
  
Phenytoin (Dilantin, Phenytek)
Omeprazole can increase the level of phenytoin in your blood, increasing your risk of phenytoin side effects. Your healthcare provider may need to decrease your phenytoin dosage.
 
Rifampin
Rifampin may significantly decrease the level of omeprazole in the blood, making it less effective. These medications should not be combined.
 
St. John's Wort
St. John's wort may significantly decrease the level of omeprazole in the blood, making it less effective. These medications should not be combined.
  
Tacrolimus (Prograf)
Omeprazole can increase the level of tacrolimus in your blood, increasing your risk of tacrolimus side effects. Your healthcare provider may need to check your tacrolimus blood level and adjust your dose as necessary.
 
Voriconazole (Vfend)
Voriconazole can double the amount of omeprazole in your blood, increasing your risk of side effects. Typically, this is a significant problem only for people taking a very high omeprazole dosage. However, you should talk to your healthcare provider before using these medications together.
  
Warfarin (Coumadin, Jantoven)
Omeprazole can increase the level of warfarin in your blood, increasing your risk of bleeding. Your healthcare provider should monitor you closely and adjust your warfarin dose as necessary.
 
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