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Drug Interactions With Omeprazole

Omeprazole Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when omeprazole is combined with any of the drugs listed above.
 
Ampicillin (Principen)
Omeprazole can decrease the absorption of ampicillin into your bloodstream, perhaps making it less effective. Your healthcare provider may need to increase your ampicillin dose.
 
Cilostazol
Omeprazole may increase the level of cilostazol in the blood. If you must take these two medications together, your healthcare provider should consider lowering your cilostazol dosage (to perhaps 50 mg twice daily).
  
Citalopram (Celexa)
Omeprazole may increase the level of citalopram in your blood, perhaps increasing your risk of citalopram side effects. Your healthcare provider may need to decrease your citalopram dosage.
 
Clopidogrel (Plavix)
Some research suggests that omeprazole may decrease the effectiveness of clopidogrel. This could potentially be a serious drug interaction. However, experts are still in disagreement about how significant this interaction really is. Do not combine these medications without discussing the matter with your healthcare provider first.
  
Diazepam (Valium)
Omeprazole can increase the level of diazepam in your blood, increasing your risk of diazepam side effects. Your healthcare provider may need to decrease your diazepam dosage.
 
Digoxin
Omeprazole may decrease the absorption of digoxin into the bloodstream. Your healthcare provider may decide to monitor your digoxin levels using a simple blood test, especially when you start or stop taking omeprazole. Omeprazole may cause low blood magnesium levels, which can lead to serious arrhythmias (irregular heart rhythms), especially in people taking digoxin. Your healthcare provider may decide to monitor your magnesium levels periodically if you are taking digoxin and omeprazole.
 
Certain Diuretics 
Omeprazole can cause low blood magnesium (hypomagnesemia). Because certain diuretics can also cause this problem, combining omeprazole with one of these diuretics could cause severely low blood magnesium levels, which may lead to serious side effects such as muscle spasms, irregular heart rhythms, or seizures. Your healthcare provider may decide to monitor magnesium levels periodically if you are taking omeprazole with one of these diuretics.
 
Erlotinib
Omeprazole may decrease the absorption of erlotinib, perhaps making it less effective. Your healthcare provider may recommend an alternative to omeprazole while you are taking erlotinib.
   
Escitalopram (Celexa)
Omeprazole may increase the level of escitalopram in your blood, perhaps increasing your risk of escitalopram side effects. Your healthcare provider may need to decrease your escitalopram dosage.
 
HIV Medications
Omeprazole can interact with some HIV medications. Depending on the medication, it could decrease the level of the medication in the blood (making it less effective) or increase the level (increasing the risk of side effects). Check with your healthcare provider before combining omeprazole with any HIV medications.
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