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Drug Interactions With Omeprazole/Sodium Bicarbonate

Drug Interactions With Omeprazole/Sodium Bicarbonate Explained

The following sections explain in detail the potentially negative interactions that can occur when omeprazole/sodium bicarbonate is combined with any of the drugs listed above.
 
Ampicillin
Omeprazole/sodium bicarbonate can decrease the absorption of ampicillin into your bloodstream, perhaps making it less effective. Your healthcare provider may need to increase your ampicillin dose to prevent this interaction from occurring.
 
Cilostazol
Omeprazole/sodium bicarbonate may increase the level of cilostazol in the blood. If you must take these two medications together, your healthcare provider should consider lowering your cilostazol dosage (to perhaps 50 mg twice daily).
 
Clarithromycin
Taking clarithromycin and omeprazole/sodium bicarbonate together may increase the level of both medications in your blood. Check with your healthcare provider before taking these drugs together.
 
Clopidogrel
Clopidogrel is metabolized into its active form by certain liver enzymes known as CYP 2C19 enzymes. Omeprazole/sodium bicarbonate can inhibit these enzymes, perhaps decreasing the effectiveness of clopidogrel. In general, it is usually best to avoid taking these medications together.
 
Diazepam
Omeprazole/sodium bicarbonate can increase the level of diazepam in your blood, possibly increasing your risk of diazepam side effects. Your healthcare provider may need to decrease your diazepam dosage as a result.
 
Digoxin
Omeprazole/sodium bicarbonate may decrease the absorption of digoxin into the bloodstream. Your healthcare provider may decide to monitor your digoxin levels using a simple blood test, especially when you start or stop taking omeprazole/sodium bicarbonate. Omeprazole/sodium bicarbonate may cause low blood magnesium levels, which can lead to serious arrhythmias (irregular heart rhythms), especially in people taking digoxin. Your healthcare provider may decide to monitor magnesium levels periodically if you are taking digoxin and omeprazole/sodium bicarbonate.

Omeprazole/Sodium Bicarbonate Drug Information

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