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Nicotine Nasal Spray Side Effects

Nasal irritation is the most commonly reported side effect of nicotine nasal spray. It usually goes away after a few days, but can persist. In general, most people tolerate this medication well and side effects, if they occur, are mild and easily treated. However, there are some potentially serious problems to be aware of, such as allergic reactions, nasal ulcers, and nicotine overdose.

An Introduction to Nicotine Nasal Spray Side Effects

As with any medicine, nicotine nasal spray (Nicotrol® NS) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with nicotine nasal spray. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Nicotine Nasal Spray

Some possible side effects of nicotine nasal spray should be reported immediately to your healthcare provider. These include but are not limited to:
  • Nose or throat irritation that is severe or does not go away after a few weeks of use
  • Ulcers or blisters in the nose
  • Feelings of dependence on the nasal spray
  • Persistent heartburn or indigestion
  • An irregular, rapid, or forcefully beating heart (arrhythmias or palpitations)
  • Increased blood pressure
  • Problems breathing, such as shortness of breath or wheezing
  • Symptoms of a nicotine overdose, such as:
    • Nausea and vomiting
    • Sweating
    • Extreme dizziness
    • Diarrhea
    • Weakness
    • A rapid heartbeat
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing or difficulty breathing
    • Difficulty swallowing.
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