High Triglycerides
High levels of
triglycerides (the fat-like substances in the body) in the blood can have many negative effects on the body. They can accumulate on the walls of arteries, which decreases the blood flow and oxygen supply to the heart, brain, and other parts of your body.
High triglycerides can also increase a person's risk of developing
heart disease,
angina, a
heart attack, and a
stroke.
Very high levels of triglycerides can produce a condition known as
pancreatitis (inflammation of the
pancreas). Pancreatitis can be very painful and can sometimes cause serious health problems.
Niacin extended-release has been licensed to treat high triglycerides, in combination with diet and exercise. It works by increasing the breakdown and removal of these fat-like substances so there is less of them in the body.
High Cholesterol and Coronary Artery Disease (CAD)
Niacin extended-release has been licensed, in combination with a bile acid sequestrant (
cholestyramine,
colestipol,
colesevelam), to help slow the progression of atherosclerosis in patients with both high
cholesterol and coronary artery disease. It works by decreasing cholesterol and triglyceride levels, which lead to atherosclerosis by accumulating on the arteries of the heart.
Niacin Extended-Release as One Part of Treatment
Lowering triglycerides and cholesterol should begin with lifestyle modifications. This includes a diet low in cholesterol and saturated fats, limited alcohol use, weight loss, and exercise. If lifestyle changes alone do not
reduce cholesterol or triglyceride levels to a desirable level, certain medications, such as niacin extended-release, may be necessary.
Since niacin extended-release can lower both
LDL cholesterol and triglyceride levels (along with lowering total cholesterol and increasing
HDL), a person can decrease his or her risk of developing certain health problems in the future.
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