Side Effects of Niacin Extended-Release/Simvastatin

Serious Side Effects Seen With Niacin Extended-Release/Simvastatin

There are several side effects that you should report immediately to your healthcare provider. These include, but are not limited to:
 
  • Muscle pain, tenderness, or weakness, especially if you also have a fever or feel ill, since these may be signs of serious breakdown of muscle, known as rhabdomyolysis (see Simcor and Muscle Pain)
  • Significant, unexplained changes in the amount of urine you produce (which may be a sign of kidney problems)
  • Signs of liver damage (see Simcor and Liver Problems), such as:

 

    • Yellowing of the whites of the eyes or skin (jaundice)
    • Upper-right abdominal pain (stomach pain)
    • Dark urine
    • High liver enzymes (found using a blood test)

 

  • Signs of a stomach ulcer, such as:

 

    • Severe heartburn
    • Stomach pain
    • Loss of appetite
    • Dizziness
    • Vomiting blood
    • Blood in the stool (seen as dark-colored stools)

 

  • Easy bruising or bleeding (or bleeding that is slow to stop)
  • Gout
  • High blood sugar (hyperglycemia)
  • Signs of low blood pressure (hypotension), such as lightheadedness, dizziness, or fainting
  • An irregular heart rhythm (arrhythmia)
  • Signs of an allergic reaction, such as:

 

    • A rash
    • Itching
    • Joint pain
    • Anemia
    • Low white blood cell counts
    • Sensitivity to the sun
    • Fever and chills
    • Flushing
    • A general ill feeling
    • Hives
    • Wheezing or difficulty breathing
    • Swelling of the mouth, tongue, or throat.

 

(Side Effects of Niacin Extended-Release/Simvastatin Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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