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Niacin Extended-Release/Simvastatin Dosage

The recommended starting dosage of niacin extended-release/simvastatin for most people with high cholesterol is 500/20 mg once a day. Your healthcare provider can increase your dosage as needed, up to a maximum of 2000/40 mg (two 1000/20 mg tablets) once daily. It is recommended that you take your dose at bedtime with a low-fat snack.

An Introduction to Niacin Extended-Release/Simvastatin Dosing

The dosage of niacin extended-release/simvastatin (Simcor®) that your healthcare provider recommends will vary, depending on a number of factors, including:
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Dosage for High Cholesterol

The recommended starting niacin extended-release/simvastatin dose for most people with high cholesterol is 500/20 mg once a day, taken at bedtime with a low-fat snack.
Your healthcare provider may increase your dose if necessary. This must be done slowly, to minimize liver problems as well as flushing due to the niacin component of the medication. It is recommended to increase the dose no more rapidly than by 500 mg (based on the niacin component) every four weeks. The dosage can also be decreased if side effects occur. The maximum recommended daily dosage of niacin extended-release/simvastatin is 2000/40 mg (two 1000/20 mg tablets) once daily.
In order to minimize flushing, your healthcare provider may recommend taking aspirin or other similar nonsteroidal anti-inflammatory drugs (NSAIDS), such as ibuprofen. This works best if you take the aspirin or NSAID about 30 minutes before your dose of niacin extended-release/simvastatin. Be sure to check with your healthcare provider first, since there may be a reason why you should not take aspirin or an NSAID.
There is no way to take less than 20 mg of the simvastatin component while taking niacin extended-release/simvastatin, since the tablets cannot be split. Therefore, if a lower simvastatin dosage is recommended in your particular situation, this medication is not a good choice for you.
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Niacin Extended-Release/Simvastatin Information

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