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Drug Interactions With Niacin Extended-Release/Simvastatin

Certain Antifungals
Some antifungal medications may increase the level of niacin extended-release/simvastatin in your blood, increasing the risk of side effects, including dangerous side effects such as myopathy or rhabdomyolysis. These medications should not be taken together with niacin extended-release/simvastatin; instead, alternative antifungals should be recommended. If no suitable alternatives are available, you should stop taking niacin extended-release/simvastatin while taking the antifungal.
 
Cyclosporine
Taking both cyclosporine and niacin extended-release/simvastatin together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments.
 
Fibrates
Combining a fibrate with niacin extended-release/simvastatin increases the risk of serious muscle problems. This combination should be avoided unless the potential benefits outweigh the risks of the drug interaction.
 
Danazol
Taking both danazol and niacin extended-release/simvastatin together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments.
 
Digoxin
Niacin extended-release/simvastatin may slightly increase the level of digoxin in the blood. Your healthcare provider may want to monitor your digoxin levels when you start or stop taking niacin extended-release/simvastatin (or even when changing your niacin extended-release/simvastatin dosage).
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Niacin Extended-Release/Simvastatin Information

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