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Drug Interactions With Niacin Extended-Release/Simvastatin

More Details About Niacin Extended-Release/Simvastatin Drug Interactions

The following sections explain in detail the potentially negative interactions that can occur when niacin extended-release/simvastatin is combined with any of the drugs listed above.
 
Amiodarone
Taking both amiodarone and niacin extended-release/simvastatin increases the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments.
 
Bile Acid Sequestrants
Bile acid sequestrants bind to niacin (one of the active ingredients of niacin extended-release/simvastatin) in the digestive tract, preventing it from being absorbed into the bloodstream. This makes niacin extended-release/simvastatin much less effective. Be sure to separate niacin extended-release/simvastatin and a bile acid sequestrant by as much time as possible, at least four to six hours.
 
Blood Pressure Medications
Combining niacin extended-release/simvastatin with a high blood pressure medication may increase the risk of low blood pressure (hypotension). Be sure to let your healthcare provider know if you develop any signs of this problem, such as lightheadedness, dizziness, or fainting. Check with your healthcare provider before combining niacin extended-release/simvastatin with a blood pressure medication.
 
Certain Antibiotics
Some antibiotics may increase the level of niacin extended-release/simvastatin in your blood, increasing the risk of side effects, including dangerous side effects such as myopathy or rhabdomyolysis. These medications should not be taken together with niacin extended-release/simvastatin; instead, alternative antibiotics should be recommended. If no suitable alternatives are available, you should stop taking niacin extended-release/simvastatin while taking the antibiotic.
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Niacin Extended-Release/Simvastatin Information

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