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Side Effects of Niacin Extended-Release/Lovastatin

Flushing, headaches, and infections are some of the more common side effects that have been reported with niacin extended-release/lovastatin. Side effects of the medicine are typically mild, but up to 19 percent of people in clinical studies stopped taking it because of side effects. Potentially serious side effects that require medical attention include difficulty breathing, stomach pain, and easy bruising.

An Introduction to Niacin Extended-Release/Lovastatin Side Effects

As with any medicine, side effects are possible with niacin extended-release/lovastatin (Advicor®). However, not everyone who takes the drug will experience side effects. Most people have no problems with it. If side effects do occur, in most cases, they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with niacin extended-release/lovastatin. Your healthcare provider can discuss a more complete list of niacin extended-release/lovastatin side effects with you.)

Serious Side Effects Seen With Niacin Extended-Release/Lovastatin

Several side effects with niacin extended-release/lovastatin are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
    • Fatigue
    • Loss of appetite
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Upper-right abdominal pain (stomach pain)
    • Dark urine
    • High liver enzymes (found using a blood test)
  • Signs of a stomach ulcer, such as:
    • Severe heartburn
    • Stomach pain
    • Loss of appetite
    • Dizziness
    • Vomiting blood
    • Blood in the stool (seen as dark-colored stools)
  • Easy bruising or bleeding (or bleeding that is slow to stop)
  • Sudden, severe pain, redness, and swelling of the joints (especially the joints of the feet, ankles, hands, and wrists), which could be a sign of gout
  • Signs of low blood pressure (hypotension), such as lightheadedness, dizziness, or fainting
  • Problems with your memory, forgetfulness, or confusion 
  • An irregular heart rhythm (arrhythmia)
  • Muscle pain, tenderness, or weakness, especially if you also have a fever or feel ill; these may be signs of serious breakdown of muscle, known as rhabdomyolysis (see Advicor and Muscle Pain)
  • Significant, unexplained changes in the amount of urine you produce (which may be a sign of kidney problems)
  • High blood sugar levels, increased thirst, or frequent urination 
  • Signs of an allergic reaction, such as:
    • A rash
    • Itching
    • Joint pain (see Advicor and Joint Pain)
    • Anemia
    • Low white blood cells counts
    • Sensitivity to the sun
    • Fever and chills
    • Flushing
    • A general ill feeling
    • Hives
    • Wheezing or difficulty breathing
    • Swelling of the mouth, tongue, or throat.
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Niacin Extended-Release and Lovastatin Information

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