Side Effects of Niacin Extended-Release/Lovastatin

Common Niacin Extended-Release/Lovastatin Side Effects

Niacin extended-release/lovastatin has been studied in clinical trials, with hundreds of people having been evaluated. In these studies, side effects were documented and compared to side effects that occurred in a similar group of people taking either lovastatin or extended-release niacin alone (rather than the combination of the two).
 
Based on these studies, the most common side effects of niacin extended-release/lovastatin included:
 
  • Flushing -- in up to 71 percent of people
  • Infection -- up to 20 percent
  • Headaches -- up to 9 percent
  • Pain -- up to 8 percent
  • Nausea -- up to 7 percent.
     
Other commonly reported side effects (occurring in 3 to 6 percent of people) included:
 
  • Vomiting
  • High blood sugar (hyperglycemia)
  • General feeling of weakness (asthenia)
  • Flu
  • Back pain
  • Abdominal pain (stomach pain)
  • Diarrhea
  • Indigestion (dyspepsia)
  • Nausea
  • Itchy skin
  • Unexplained rash
  • Muscle pain (see Advicor and Muscle Pain).
     

Niacin Extended-Release/Lovastatin and Tumors

The niacin component of this combination medication has not been associated with cancer or tumors. However, the lovastatin component has been shown to increase the risk of several different types of tumors or cancer in laboratory animals. However, statin medications (like lovastatin) have not been linked to cancer in humans; in fact, several researchers believe that statins might actually help prevent cancer.
 
(Side Effects of Niacin Extended-Release/Lovastatin Continued: Page 4)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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