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Niacin Extended-Release/Lovastatin

How Does Niacin Extended-Release/Lovastatin Work?

Lovastatin is part of a class of drugs called statins. It works by blocking a particular enzyme (HMG-CoA reductase) that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. It also increases the liver's ability to collect and get rid of LDL cholesterol.
Niacin, or nicotinic acid, is also used as a cholesterol-lowering medicine. How niacin works is not completely understood. Niacin is believed to increase HDL cholesterol ("good" cholesterol) levels by preventing the liver from removing HDL from the bloodstream. In addition, niacin seems to decrease the liver's production of LDL and VLDL, two types of "bad" cholesterol. It also helps decrease the release of fatty acids (from body fat) into the bloodstream.
Because of the effects of lovastatin and niacin, the combination drug can help decrease the following forms of cholesterol and fats:
Niacin extended-release/lovastatin also increases HDL cholesterol (good cholesterol).

Clinical Effects

In research studies, people taking niacin extended-release/lovastatin 1000 mg/20 mg once in the evening were able to, on average, decrease LDL cholesterol by 30 percent, decrease triglycerides by 32 percent, and increase HDL by 20 percent. Generally, the effects of niacin extended-release/lovastatin on cholesterol and triglyceride levels were greater with higher doses.
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Niacin Extended-Release and Lovastatin Information

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