Drug Interactions With Niacin Extended-Release/Lovastatin

Bile acid sequestrants, cyclosporine, and protease inhibitors are some of the medications that may cause drug interactions with niacin extended-release/lovastatin. Some of these interactions can increase your risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Interactions could also increase your risk of other side effects and affect the drug levels in your blood.

Niacin Extended-Release/Lovastatin Interactions: An Overview

Niacin extended-release/lovastatin (Advicor®) can potentially interact with a number of other medicines. Some of the medications that may lead to drug interactions with niacin extended-release/lovastatin include:
 
 
 
 
 
  • Certain antifungals, such as:
 
    • Fluconazole (Diflucan®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Posaconazole (Noxafil®)
    • Voriconazole (VFEND®)
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Danazol (Danocrine®)
  • Fibrates, such as:
 
 
 
    • Isosorbide dinitrate (BiDil®, Dilatrate® SR, Isochron™, Isordil®)
    • Isosorbide mononitrate (Imdur®, Ismo®, Monoket®)
    • Nitroglycerin tablets or capsules (Nitroquick®, Nitrostat®, Nitro-Time®)
    • Nitroglycerin ointment (Nitro-Bid®)
    • Nitroglycerin patches (Minitran®, Nitrodisc®, Nitro-Dur®, Transderm-Nitro®, Transderm-NTG®)
    • Nitroglycerin spray (Nitrolingual®)
 
  • Protease inhibitors, such as:
 
 
Some of these niacin extended-release/lovastatin drug interactions may increase your risk for developing serious muscle problems (see Advicor and Muscle Pain). If you are taking niacin extended-release/lovastatin and experience unexplained muscle pain, tenderness, or weakness (especially if accompanied by a fever or feeling of illness), it is important to contact your healthcare provider right away.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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