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Drug Interactions With Niacin Extended-Release/Lovastatin

Certain Antifungals
Some antifungal medications may increase the level of niacin extended-release/lovastatin in your blood, increasing the risk of side effects of niacin extended-release/lovastatin, including dangerous problems such as myopathy or rhabdomyolysis. These medications should not be taken with niacin extended-release/lovastatin; instead, alternative antifungals should be recommended. If no suitable alternatives are available, you should stop taking niacin extended-release/lovastatin while taking the antifungal.
 
Colchicine
There have been reports of serious muscle problems, including rhabdomyolysis, occurring in people who took colchicine with niacin extended-release/lovastatin. If you take these medications together, be sure to immediately report to your healthcare provider any unexplained muscle pain or weakness.
  
Cyclosporine
Taking cyclosporine and niacin extended-release/lovastatin together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. These medications should generally not be taken together.
 
Danazol
Taking both danazol and niacin extended-release/lovastatin together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. These medications should only be used together if the benefits of using them outweigh the potential risks of muscle problems. If you take these medications together, the lovastatin component of your niacin extended-release/lovastatin dose should not exceed 20 mg a day.
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Niacin Extended-Release and Lovastatin Information

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