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Drug Interactions With Niacin Extended-Release/Lovastatin

More Information on Interactions With Niacin Extended-Release/Lovastatin

The following sections explain in detail the potentially negative interactions that can occur when niacin extended-release/lovastatin is combined with any of the drugs listed above.
Taking both amiodarone and niacin extended-release/lovastatin increases the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. If you take these medications together, the lovastatin component of your niacin extended-release/lovastatin dose should not exceed 40 mg a day.
Bile Acid Sequestrants
Bile acid sequestrants bind to niacin (one of the active ingredients of niacin extended-release/lovastatin) in the digestive tract, preventing it from being absorbed into the bloodstream. This makes this medication much less effective. Be sure to separate niacin extended-release/lovastatin and a bile acid sequestrant by as much time as possible, at least four to six hours.
Blood Pressure Medications
Combining niacin extended-release/lovastatin with a high blood pressure medication may increase the risk of low blood pressure (hypotension). Be sure to let your healthcare provider know if you develop any signs of this problem, such as lightheadedness, dizziness, or fainting. Check with your healthcare provider before combining these medications, especially if you have recently had a heart attack or if you have unstable angina (a certain type of chest pain).
Boceprevir can increase blood levels of niacin extended-release/lovastatin, thereby increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Because of this risk, these medications should not be used together.
Certain Antibiotics
Some antibiotics may increase the level of niacin extended-release/lovastatin in your blood, increasing the risk of side effects, including dangerous side effects such as myopathy or rhabdomyolysis. These medications should not be taken with niacin extended-release/lovastatin; instead, alternative antibiotics should be recommended. If no suitable alternatives are available, you should stop taking niacin extended-release/lovastatin while taking the antibiotic.
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Niacin Extended-Release and Lovastatin Information

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