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Drug Interactions With Naltrexone

More Detail on Drug Interactions With Naltrexone

The following sections explain in detail the potentially negative interactions that can occur when naltrexone is combined with any of the drugs listed above.
Cannabinoids are sometimes used to help relieve nausea, vomiting, and pain. Naltrexone may interact with cannabinoids by either increasing or decreasing their effects. If you take naltrexone, let your healthcare provider know if you are being treated with a cannabinoid or use cannabinoid products. 
Both disulfiram and naltrexone can cause liver damage. The manufacturer of naltrexone recommends these medicines not be used together, unless a healthcare provider determines the possible benefit of the combination outweighs the potential risks.
Opioid medications may not be effective in people taking naltrexone. If an opioid is needed in an emergency situation, larger-than-normal opioid doses may be required, which could cause potentially serious side effects, such as severe respiratory depression (slow and shallow breathing). 
If you have been taking an opioid, starting naltrexone may cause severe opioid withdrawal symptoms, which may be more serious than normal withdrawal symptoms. In general, you need to be off all opioids for one to two weeks before starting naltrexone. The exact amount of time depends on which opioid you were taking.
The combination of naltrexone and thioridazine has been reported to cause lethargy and drowsiness. Let your healthcare provider know if you are taking thioridazine before starting naltrexone.

Final Thoughts

It is possible that not all naltrexone drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
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Naltrexone Medication Information

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