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Naltrexone Injection Side Effects

Your healthcare provider needs to know right away if you have blurred vision, difficulty breathing, extreme swelling, or other serious side effects when using naltrexone injection. In most cases, however, people are able to use the drug without many problems. Some of the most commonly reported side effects include nausea, headaches, and insomnia.

An Introduction to Side Effects With Naltrexone Injection

As with any medicine, naltrexone injection (Vivitrol®) can cause side effects. However, not everyone who uses the medication will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with naltrexone injection. Your healthcare provider can discuss a more complete list with you.)

Serious Naltrexone Injection Side Effects

Some side effects of naltrexone injections are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Severe reactions at the site of the injection, such as:
    • Intense pain
    • Hardening of the skin in the area
    • Extreme swelling
    • Lumps
    • Blisters
    • A dark scab
    • An open wound
    • A sore or reaction that does not improve within two weeks or gets worse
  • Breathing problems, such as shortness of breath or wheezing
  • A new or persistent cough
  • Feeling sad or depressed
  • Thoughts of suicide or harming yourself
  • Unusual behavior or mood, including irritability, agitation, or anxiety
  • Seeing or hearing things that are not real
  • Feeling disoriented, confused, or paranoid
  • Swelling, pain, warmth, or redness in an arm or leg
  • A fast, forceful, or irregular heartbeat
  • Blurred vision
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Abdominal (stomach) pain
    • Loss of appetite
    • Dark urine
    • Pale or clay-colored stool
  • Signs of opioid withdrawal, such as:
    • Tearfulness
    • Nausea and vomiting
    • Abdominal (stomach) cramps
    • Restlessness
    • Bone, joint, or muscle pain
    • Runny or stuffy nose
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives 
    • Swelling of the face, mouth, or throat
    • Difficulty breathing or wheezing
    • Chest pain
    • Dizziness or fainting.  
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Naltrexone Injection Information

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