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Naloxone Side Effects

Contact your healthcare provider if you develop serious side effects of naloxone, such as seizures, hallucinations, or a rapid heart rate. In most cases, however, people tolerate this medication well, and any reactions that do occur are typically easy to treat. Other potential problems include hot flashes, nausea, and trembling.

An Introduction to Side Effects of Naloxone

As with any medicine, naloxone hydrochloride (Narcan®) can cause side effects. However, not everyone who uses the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with naloxone. Your healthcare provider can discuss a more complete list with you.)

Serious Naloxone Side Effects

Some side effects of naloxone are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Agitation
  • Significant pain
  • Lightheadedness or fainting
  • A fast, irregular, or forcefully beating heart
  • Seizures
  • Signs of opioid withdrawal, such as:
    • Body aches
    • Fever
    • Sweating
    • Runny nose
    • Goosebumps
    • Yawning
    • Weakness
    • Shivering or trembling
    • Nervousness, restlessness, or irritability
    • Diarrhea
    • Nausea and vomiting
    • Abdominal (stomach) cramps
    • Increased blood pressure (hypertension)
  • Excessive crying in infants
  • Abnormal, involuntary movements
  • Extreme shortness of breath or difficulty breathing
  • Numbness, burning, pricking, or other unusual sensations of the skin
  • Seeing or hearing things that are not real (hallucinations)
  • Slow, shallow, or irregular breathing
  • Chest pain
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.  
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Naloxone Drug Information

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