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Naloxone

Important Information for Your Healthcare Provider

Talk with your healthcare provider prior to using naloxone if you have:
 
  • Been taking opioid medicines, either for a medical or nonmedical reason
  • Been using illegal or street drugs
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Heart disease
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
   
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Naloxone to learn more, including information on who should not receive the drug.)
 

How Does It Work?

It is not completely known how naloxone works. The drug is thought to work by competing with opioids for opioid receptors. Naloxone binds to opioid receptors, but produces no effects. Instead, it prevents opioid medicines from also binding to the receptors, thus blocking their actions.
 
There are several types of opioid receptors located throughout the body. Naloxone is thought to bind to mu, kappa, and sigma opioid receptors, but has its greatest effects at mu receptors.
 
The effects of naloxone may be shorter than those of some opioids. This means, in some cases, the drug may need to be given in repeated doses until the opioid medicine is no longer active in the body.
 
Drink Less Alcohol

Naloxone Drug Information

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