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Naloxone Dosage

Various factors affect the dose of naloxone you are prescribed, such as your age, how you respond to the drug, and the reason you are receiving it. This medication comes as a liquid that your healthcare provider will inject into a vein, muscle, or under the skin. Because the effects of naloxone may be shorter than those of some opioids, repeated doses may be needed.

An Introduction to Your Dosage of Naloxone

The dose of naloxone hydrochloride (Narcan®) your healthcare provider recommends will vary, depending on a few factors, including:
  • Your age
  • Your weight (for children)
  • The reason you are receiving the medication
  • How you respond to it. 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Naloxone Dosing Guidelines

In general, dosages of naloxone can vary significantly from person to person. Your healthcare provider will choose the best dose for you based on your individual situation.
Usual naloxone doses in adults following an opioid overdose can range from 0.4 mg to 2 mg. Because the effects of this drug may be shorter than those of some opioids, doses of naloxone may be need to be repeated every two to three minutes, if necessary.
Smaller amounts are usually needed to reverse respiratory depression (slow and shallow breathing) after surgery and can range from 0.1 mg to 0.2 mg, every two to three minutes, until a person is adequately alert and breathing.
Usual amounts of naloxone for reversing an opioid overdose in children are based on body weight. Specifically, the initial recommended dose is 0.01 mg per kg body weight (about 0.0045 mg per lb). If the first dose does not seem adequate, a larger amount, 0.1 mg per kg (about 0.045 mg per lb), may be given if needed. 
The usual naloxone dosage for reversing respiratory depression in children after surgery is 0.005 mg to 0.01 mg every two to three minutes.
Drink Less Alcohol

Naloxone Drug Information

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