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Drug Interactions With Naloxone

Several medications can cause negative drug interactions with naloxone, including marijuana, heroin, and oxycodone. These interactions could increase your risk for withdrawal symptoms or decrease the effectiveness of naloxone. To ensure a safe treatment process, tell your healthcare provider about all other medications you are taking, including nonprescription medications and any illegal or street drugs.


An Overview of Naloxone Interactions

Naloxone hydrochloride (Narcan®) may react with a few other medications. Some of the products that can lead to drug interactions with naloxone include but are not limited to:
  • Cannabinoids, such as:
  • Illegal or street drugs

More Detail on Drug Interactions With Naloxone

The following sections explain in detail the potentially negative interactions that can occur when naloxone is combined with any of the drugs listed above.
Cannabinoids are sometimes used to help relieve nausea, vomiting, and pain. Naloxone has been shown to both increase and decrease the effects of these drugs. Let your healthcare provider know if you are being treated with a cannabinoid.  
Illegal or Street Drugs
Naloxone could potentially cause withdrawal symptoms in people who use certain illegal or street drugs. Make sure your healthcare provider knows about all of the drugs you are taking, including drugs that have not been prescribed for you.
Naloxone can cause withdrawal symptoms in people who are taking opioid medicines. It may also block the pain-relieving effects of these drugs.
Partial or Mixed Opioid Agonists/Antagonists
Higher doses of naloxone may be needed when treating overdoses or respiratory depression caused by partial opioid agonists (as opposed to full agonists) or opioids that are part agonist and part antagonist, which means they bind to and activate certain opioid receptors while blocking certain other opioid receptors. Naloxone may also be less effective for treating respiratory depression from mixed opioid agonists/antagonists.
Drink Less Alcohol

Naloxone Drug Information

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