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Drug Interactions

Muromonab-CD3 may react with a few other medicines (see Drug Interactions With Muromonab-CD3).

What If I Overdose on This Medicine?

An overdose of this medicine can be quite dangerous. Seek immediate medical attention if you believe you may have been given too much muromonab-CD3.
(Click Orthoclone OKT3 Overdose for more information.)

What If I Miss a Dose of Muromonab-CD3?

Because muromonab-CD3 is normally given while you are in the hospital, it is unlikely that you will miss a dose. If you believe you have not received a scheduled dose of this medicine, contact your healthcare provider right away.

How Does It Work?

Transplant rejection occurs when the immune system recognizes a transplanted organ as foreign and attacks it. T-lymphocytes (a type of white blood cell, sometimes simply called T-cells) play a major role in transplant rejection.
Muromonab-CD3 is a laboratory-made antibody (a protein normally produced by the immune system) that recognizes and attaches to a specific protein found on T-cells (known as the cell differentiation cluster 3, or CD3). When muromonab-CD3 binds to CD3, it blocks the ability of T-cells to function properly. Because the T-cells cannot function properly, they are unable to attack the transplanted organ, and transplant rejection is stopped.

When and How to Receive This Medicine

Some general considerations to keep in mind during treatment with muromonab-CD3 include the following:
  • This medication is given as an injection into a vein (an intravenous, or IV, injection). It is normally given for 10 to 14 days.
  • A healthcare provider will administer your injection in a healthcare setting, such as a hospital or clinic. You will be monitored closely for serious side effects with each dose.
  • You may be given other medications with muromonab-CD3 to help reduce the risk for serious side effects.
  • For this drug to work properly, it must be used as prescribed.

Muromonab-CD3 Medication Information

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