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Drug Interactions With Mefloquine

Drug Interactions With Mefloquine Explained

The following sections explain in detail the potentially negative reactions that can occur when mefloquine is combined with any of the drugs listed above.
 
Anticonvulsants
Mefloquine may decrease anticonvulsant levels in your body, potentially making the anticonvulsant less effective and increasing your risk for seizures. If you take these medications together, your healthcare may choose to monitor your anticonvulsant blood levels.
 
Colchicine
Taking mefloquine with colchicine may increase the amount of colchicine in your body, increasing your risk for dangerous side effects. If you take these medications together, your healthcare provider may need to monitor you more closely for colchicine side effects. You may need a lower colchicine dose.
 
CYP 3A4 Inducer Medications
The body breaks down mefloquine using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining mefloquine with one of these CYP 3A4 inducers may decrease the level of mefloquine in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure mefloquine is working if you take it with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The body breaks down mefloquine using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining mefloquine with one of these CYP 3A4 inhibitors may increase the level of mefloquine in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely for side effects if you take mefloquine with a CYP 3A4 inhibitor.

Mefloquine Drug Information

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