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Precautions and Warnings With Medroxyprogesterone Subcutaneous Injection

Specific Medroxyprogesterone Subcutaneous Injection Precautions and Warnings

Some warnings and precautions to be aware of before receiving these injections include the following:
  • Medroxyprogesterone subcutaneous injection can decrease the amount of calcium stored in your bones, which can cause bone loss (osteoporosis) and increase your risk for fractures. Your bones may not return to normal even after stopping the medication. This side effect is especially concerning for adolescents and young adults, who are at a critical age for gaining bone strength, as well as for people who are already at risk for weak bones. This may include those who:
The longer you use medroxyprogesterone subcutaneous injection, the more it will affect the bones. Therefore, the medication should not be used for longer than two years, unless absolutely necessary. Also, it is a good idea for everyone who uses medroxyprogesterone subcutaneous injection to have an adequate intake of calcium and vitamin D through supplements or dietary means. Ask your healthcare provider if you are getting enough calcium and vitamin D to help protect your bones.
  • Women may notice irregular periods when they first start using medroxyprogesterone subcutaneous injection. This could include spotting, bleeding between periods, prolonged periods, or heavy bleeding. The majority of women will stop having periods altogether within 12 months of starting medroxyprogesterone subcutaneous injection. If you have persistent irregular bleeding, or an unusually heavy period, talk to your healthcare provider. These may be signs of a serious problem.
  • Medroxyprogesterone subcutaneous injection does not protect against HIV or other sexually transmitted diseases (STDs). You will need another form of contraception to protect yourself from STDs.
  • Like other hormonal contraceptives, medroxyprogesterone subcutaneous injection may increase the risk of breast cancer. It may also increase the risk of cervical cancer. Women with a history of breast cancer should not use hormonal contraceptives, including medroxyprogesterone subcutaneous injection. Women who use this medicine should receive proper screening and monitoring, such as routine mammograms.
  • Medroxyprogesterone subcutaneous injection can increase the risk for strokes and blood clots in your arms, legs, lungs, and eyes. Seek immediate medical attention if you experience signs of a stroke or blood clot, such as:
    • Changes in your vision or speech
    • A sudden, severe headache
    • Shortness of breath
    • Sudden chest pain
    • Weakness
    • Swelling
    • Pain in an arm or leg.
  • Medroxyprogesterone subcutaneous injection can increase the risk for an ectopic pregnancy, which is a pregnancy that occurs outside of the uterus. An ectopic pregnancy is a serious and potentially life-threatening condition. Seek immediate medical attention if you experience unexplained vaginal bleeding or severe abdominal (stomach) or pelvic pain, which may be signs of an ectopic pregnancy.
  • This medication can cause liver problems. Contact your healthcare provider right away if you experience yellowing of the whites of the eyes or skin (jaundice), which could be signs of liver problems.
  • Many women who use medroxyprogesterone subcutaneous injection will experience weight gain. In clinical trials, the average weight gain was 3.5 pounds after 1 year of use and 7.5 pounds after 2 years.
  • Depression is a possible side effect of medroxyprogesterone subcutaneous injection. If you have a history of depression, your healthcare provider may choose to monitor you more closely. If you develop depression while using medroxyprogesterone subcutaneous injection, you should not receive another shot.
  • Medroxyprogesterone subcutaneous injection has been reported to cause a decrease in glucose tolerance, which could be a problem for people with diabetes. If you have diabetes, your healthcare provider may recommend you test your blood sugar levels more often while using this medicine.
  • Medroxyprogesterone subcutaneous injection can cause fluid retention. This can cause problems for certain people, including those with congestive heart failure (CHF), kidney problems, asthma, or migraines. Your healthcare provider may need to monitor you more closely if you have a condition that could be affected by fluid retention.
  • Because medroxyprogesterone subcutaneous injection is a long-acting medicine, it can take many months before you are able to become pregnant after stopping the medication. In clinical studies of women who received multiple injections, it took at least six months after the last shot for ovulation (the release of an egg from an ovary) to occur. The average time to ovulation was 10 months. However, ovulation may occur much sooner after a single shot.
  • It is a good idea to have an annual healthcare exam in general, and especially while using medroxyprogesterone subcutaneous injection. Make sure to keep all of your appointments with your healthcare provider. He or she will want to check your blood pressure, and may also recommend other tests, such as a mammogram and pelvic exam (pap smear). You may need to be monitored more closely if you have irregular bleeding, breast lumps, or a family history of breast cancer.
  • Medroxyprogesterone subcutaneous injection passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to receiving this drug (see depo-subQ Provera 104 and Breastfeeding).
  • Medroxyprogesterone subcutaneous injection is a pregnancy Category X medication. This means it should not be used in pregnant women (see depo-subQ Provera 104 and Pregnancy).
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Medroxyprogesterone Subcutaneous Injection Information

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