Medroxyprogesterone Subcutaneous Injection Side Effects

While most reactions to medroxyprogesterone subcutaneous injection are generally minor, notify your healthcare provider right away if you are receiving these injections and develop a severe headache, a sudden loss of vision, or other potentially serious problems. Some common side effects of medroxyprogesterone subcutaneous injection include headaches, weight gain, and skin reactions at the injection site.

An Introduction to Side Effects of Medroxyprogesterone Subcutaneous Injection

Just like any medicine, medroxyprogesterone subcutaneous injection (depo-subQ Provera 104®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with medroxyprogesterone subcutaneous injection. Your healthcare provider can discuss a more complete list with you.)
 

Serious Medroxyprogesterone Subcutaneous Injection Side Effects

Some side effects are potentially serious and should be reported immediately to your healthcare provider.
 These include but are not limited to:
 
 
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • A severe headache
 
  • Signs of a blood clot in the lung, such as:
 
    • Shortness of breath
    • Sudden chest pain
    • Coughing up blood
 
  • Signs of a blood clot in the leg, such as severe pain or swelling of the calf
  • Severe abdominal (stomach) pain
  • Signs of liver damage, such as:
 
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal (stomach) pain
 
  • Seizures
  • Depression
  • Persistent abnormal menstrual periods or heavy vaginal bleeding
  • Injection site reactions, such as severe or persistent pain, soreness, pus, or bleeding
  • A change in blood glucose levels, especially if you have diabetes
  • Breast lumps
  • Nipple discharge or bleeding
  • Signs of an allergic reaction, such as:
 
    • Hives
    • Itching
    • Unexplained swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing or swallowing.
 
Medroxyprogesterone Subcutaneous Injection Side Effects Article Continues on Next Page >
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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