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Mecasermin Dosage

When starting mecasermin, the recommended dosage is 0.04 to 0.08 mg per kg body weight injected twice a day. The injections are to be given just under the skin (subcutaneously). Because mecasermin can cause low blood sugar levels, make sure you only give an injection if your child has eaten within 20 minutes before the injection or can eat something within 20 minutes afterwards.

 

An Introduction to Your Child's Dosage of Mecasermin

The dosage of mecasermin (Increlex®) your child's healthcare provider recommends will vary, depending on a few factors, including:
 
  • Your child's weight
  • How your child responds to the medication
  • How well your child tolerates the medicine.
 
As is always the case, do not adjust the dosage unless your child's healthcare provider specifically tells you to do so.
 

Recommended Mecasermin Dosing Guidelines

The standard recommended starting dose of mecasermin for treating short stature in children is 0.04 to 0.08 mg per kg body weight (0.018 to 0.036 mg per lb) twice a day. Your child's healthcare provider will recommend a specific amount for your child, based on your child's individual situation.
 
Mecasermin can cause low blood sugar (hypoglycemia). If your child does not develop low blood sugar after at least seven days of treatment, your child's healthcare provider may recommend a dose increase. Normally, doses are increased by 0.04 mg per kg per dose (0.018 mg per lb per dose), as tolerated. The maximum recommended dosage is 0.12 mg per kg (0.054 mg per lb) given twice daily.
 
To reduce the risk for low blood sugar, your child should eat a snack or meal within 20 minutes of each dosage. You should know the signs of low blood sugar, and learn what to do if your child's blood sugar becomes too low. Your child's healthcare provider can give you instructions.
 
You may need to monitor your child's blood glucose levels, especially at the beginning of treatment until your child is at a dosage he or she tolerates well. If your child has frequent episodes of low blood sugar, ongoing blood sugar monitoring may be necessary. If your child continues to develop low blood sugar, despite eating with each dose, his or her mecasermin dosage may need to be decreased.
 
You should always have a source of sugar nearby, in case your child experiences hypoglycemia. This could include orange juice, candy, or milk. Your child will need to carry some type of sugar at all times, especially if he or she will be away from home.
 
You will need to give your child an injection with glucagon if your child develops severe hypoglycemia and cannot respond or cannot drink sugar-containing fluids. Make sure you understand how to inject glucagon before starting mecasermin treatment, in case you need to use it. Your child's healthcare provider will teach you about glucagon and show you how to inject it.
 
Mecasermin should be given using sterile disposable syringes and needles. The pharmacy that supplies your medicine can also supply syringes and needles. If you will be using syringes that measure doses in units, make sure you know how many units to use. Your pharmacist or healthcare provider can convert your child's dosage to units if necessary.
 
7 Easy Tips for Starting Solids

Mecasermin Drug Information

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