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Maxipime Warnings and Precautions

Due to the potentially serious and even life-threatening complications that can occur with Maxipime, make sure your healthcare provider is aware if you have kidney problems, allergies to penicillins, or any other medical issues. There are also safety precautions and warnings against combining Maxipime with certain medications, vitamins, and herbal supplements. There may also be problems for women who are pregnant or nursing.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving Maxipime® (cefepime) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • An allergy to cephalosporin or penicillin antibiotics
  • Any other allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Maxipime

Some warnings and precautions to be aware of prior to using this medicine include the following:
  • Maxipime contains an antibiotic that belongs to the cephalosporin group of antibiotics, which are related to penicillin antibiotics. Some people who are allergic to penicillins will also be allergic to Maxipime. An allergic reaction can be quite dangerous. Let your healthcare provider know immediately if you notice any signs of an allergic reaction, such as:
    • A rash
    • Itching
    • Hives
    • Wheezing
    • Swelling of the mouth or lips
    • Difficulty breathing.
  • Make sure your healthcare provider knows if you have kidney disease, as the kidneys help remove Maxipime from the body. If your kidneys are not functioning well, you will need a lower and/or less frequent dosage.
  • Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of Maxipime, bloody or watery diarrhea may be a sign of a serious reaction to the drug that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop using Maxipime and can be life-threatening.
  • Antibiotics, including Maxipime, can sometimes cause yeast infections, as they can get rid of "good" bacteria that help protect against such infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) while using this medication.
  • Alert your healthcare provider to any neurological symptoms, such as seizures, confusion, hallucinations, or coma. Such problems may happen with Maxipime dosages that are too high.
  • Maxipime should not be used to treat viruses, such as the common cold or the flu. It is completely ineffective for treating viruses, and such use can lead to bacterial resistance.
  • Maxipime is a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using this medication when pregnant (see Maxipime and Pregnancy for more information).
  • Maxipime passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk with your healthcare provider before using this drug (see Maxipime and Breastfeeding for more information).

Maxipime Drug Information

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