Drugs Home > Vandetanib Side Effects

Cancer medications such as vandetanib are associated with significant side effects. For example, many people taking vandetanib experience diarrhea, nausea, and headache. Although not as common, serious problems may also occur, including allergic reactions, yellowing of the skin, or depression. Contact your healthcare provider right away if you develop any of these symptoms.

An Introduction to Vandetanib Side Effects

Just like any cancer medicine, vandetanib (Caprelsa®) can cause side effects, some of which can be significant. Although not everyone who takes the medication will have problems, most people will experience some type of adverse reaction during treatment. Talk to your healthcare provider about ways you can manage some of these side effects.
(This article covers many, but not all, of the possible side effects with vandetanib. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Vandetanib

Some vandetanib side effects are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing or difficulty breathing
    • Difficulty swallowing
  • Severe or persistent diarrhea
  • Blurred vision
  • Depression or mood changes
  • A rash or other skin reactions, such as:
    • Dryness
    • Acne
    • Itchiness
    • Blisters or sores on your skin or in your mouth
  • Yellowing of the skin or whites of the eyes (jaundice)
  • High blood pressure (hypertension)
  • An irregular or fast heartbeat
  • Lightheadedness or fainting
  • Extreme tiredness or fatigue
  • Problems breathing, shortness of breath, or a new or worsening cough
  • Unusual bleeding or bruising
  • Black, tarry, or bloody stools
  • Coughing up blood, vomiting blood, or vomit that looks like coffee grounds
  • Difficulty seeing or speaking, confusion, loss of coordination, weakness in an arm or leg, or a severe headache
  • Seizures.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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