Drugs Home > Tolvaptan Side Effects

Clinical studies have shown that a decreased appetite, lack of energy, and a dry mouth are among the most common side effects of tolvaptan. Although reactions to this medication tend to be minor and easy to treat, serious reactions can also occur. Contact your healthcare provider right away if you develop problems like confusion, muscle weakness, or trouble speaking.

An Introduction to Side Effects of Tolvaptan

As with any medicine, tolvaptan (Samsca®) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with tolvaptan. Your healthcare provider can discuss a more complete list with you.)

Serious Tolvaptan Side Effects

Some side effects should be reported immediately to your healthcare provider. These potential reactions include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing
  • Signs of a serious condition known as osmotic demyelination syndrome, which can happen when sodium levels are increased too quickly, including:
    • Trouble speaking or swallowing
    • Problems controlling your muscles
    • Muscle weakness, especially in the arms and legs
    • Drowsiness
    • Confusion
    • Changes in mood
    • Seizures
  • Dizziness or fainting
  • Persistent vomiting or diarrhea, especially if you cannot keep down fluids
  • Stools that are bright red, maroon, black, or tarry
  • Vomiting blood or vomit that looks like coffee grounds
  • Signs of dehydration, such as:
    • Feeling very thirsty
    • Decreased urination
    • Dry mouth or skin.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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