Drugs Home > Tolvaptan

When and How to Take This Medicine

Some general considerations to keep in mind during treatment with tolvaptan include the following:
 
  • Tolvaptan comes in tablet form. It is usually taken by mouth once a day.
 
  • You can take tolvaptan with food or on an empty stomach.
 
  • You will need to start tolvaptan in the hospital so you can be closely monitored at the beginning of treatment.
 
  • Try to take this medication at the same time each day to keep an even level of the drug in your blood.
 
  • You should continue to drink fluids if you are thirsty during treatment with tolvaptan.
 
  • Do not drink grapefruit juice while taking this medicine. Grapefruit juice can increase the amount of tolvaptan in your blood.
 
  • For the medication to work properly, it must be taken as prescribed. Do not stop and restart this medicine on your own. If you stop taking it, you will need to restart it in the hospital.
 

Dosing Information for Tolvaptan

The dose of tolvaptan your healthcare provider recommends will vary, depending on:
 
  • How you respond to it
  • Other medications you are taking.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 
(Click Tolvaptan Dosage for more information.)
 

Drug Interactions

Tolvaptan may react with many other medicines (see Drug Interactions With Tolvaptan)
 

What If I Take an Overdose of This Drug?

An overdose with tolvaptan may cause high blood sodium levels, thirst, frequent urination, and dehydration. If you take too much of this medication, seek immediate medical attention.
 
(Click Samsca Overdose for more information.)
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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