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- An inability to tell if you are thirsty
- An inability to make urine
- Kidney disease, such as kidney failure
- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Severe dehydration or malnutrition
- Alcoholism or drink large amounts of alcohol
- Any allergies, including to foods, dyes, or preservatives.
- Pregnant or thinking of becoming pregnant (see Samsca and Pregnancy)
- Breastfeeding (see Samsca and Breastfeeding).